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Glycosphingolipid Dysregulation in Congenital Disorders of Glycysolation (CDG)

KU Leuven -
Louvain

Soumettre votre candidature

Détails de l'emploi

Temps plein

Qualifications

Médecine
Doctorat
Compétences rédactionnelles
Anglais
Master

Description complète du poste

Glycosphingolipid Dysregulation in Congenital Disorders of Glycysolation (CDG)

(ref. BAP-2026-452)
Laatst aangepast: 13/07/26

The project is embedded within the department of development and regeneration KU Leuven and the Laboratory of Applies Mass Spectrometry – Metabolomics expertise center.
The candidate will collaborate closely with experts in clinical genetics, metabolomics, lipidomics, glycobiology and systems biology.

The research environment provides:

Access to unique international collections of CDG patient samples
State-of-the-art mass spectrometry infrastructure
Advanced multi-omics platforms
Extensive international collaborations
Opportunities for conference participation and international training

Project

Congenital disorders of glycosylation (CDG) comprise more than 200 individually rare inherited metabolic disorders and represent one of the most rapidly expanding groups of inborn errors of metabolism. While abnormalities of protein glycosylation have traditionally been considered the primary disease mechanism, many CDG patients present with severe neurological manifestations that remain only partially understood.

Recent work from our research group has identified glycosphingolipids (GSLs), including gangliosides, as a potentially critical but underexplored disease mechanism in CDG. Because glycosphingolipids constitute the majority of glycan structures in the central nervous system and are essential for neuronal development, signalling and synaptic function, understanding their dysregulation may open entirely new therapeutic avenues.

This PhD project forms part of a larger translational research programme aimed at developing mechanism-based treatments for CDG. The successful candidate will work at the intersection of rare disease research, neuroscience, systems biology, metabolomics and lipidomics.

RESEARCH OBJECTIVES

Objective 1 - Defining glycosphingolipid abnormalities in CDG

The candidate will perform comprehensive glycosphingolipid and ganglioside profiling in an extensive collection of patient-derived fibroblasts representing multiple CDG subtypes. Using state-of-the-art lipidomics and tracer-based metabolomics, metabolic bottlenecks and pathway rerouting events will be identified. Treatment options will be explored.

Objective 2 - Investigating disease mechanisms and therapeutic opportunities

Key findings will be validated in neuronal-relevant cellular models generated through CRISPR-mediated genetic engineering and pharmacological perturbation approaches. Multi-omics integration (lipidomics, metabolomics, proteomics and transcriptomics) will be used to identify pathogenic mechanisms and nominate therapeutic interventions, including glycosphingolipid supplementation and drug repurposing strategies.

The project builds upon unique patient cohorts, extensive preliminary data, and internationally recognised expertise in congenital disorders of glycosylation.

Profile

We are looking for a highly motivated candidate who:

Holds (or will soon obtain) a Master's degree in Biomedical Sciences, Biology, Medicine, Bioengineering, Biochemistry, Biotechnology, Pharmaceutical Sciences, Bioinformatics or a related discipline

Has obtained excellent academic results

Demonstrates a strong interest in rare diseases, metabolism, neuroscience or molecular medicine

Has an interest in advanced laboratory techniques and data analysis

Possesses strong communication and scientific writing skills

Is able to work independently while thriving in a collaborative multidisciplinary team

Is fluent in English

Experience with cell culture, molecular biology, mass spectrometry, bioinformatics, programming or omics technologies is considered an asset but is not mandatory.

RESPONSIBILITIES

Conduct innovative research leading to a PhD degree

Perform experiments involving cell culture, lipidomics, metabolomics and molecular biology

Analyse and integrate complex multi-omics datasets

Present research findings at national and international meetings

Publish research in high-quality scientific journals

Participate in national and international collaborations

Support supervision of Master's thesis students

Offer

KU Leuven offers a stimulating international research environment with excellent training opportunities. The successful candidate will join a dynamic team of clinicians, PhD students, postdoctoral researchers and technicians working on rare metabolic diseases and translational therapeutic development.

Successful completion of the programme will lead to the degree of Doctor of Biomedical Sciences.

FUNDING AND APPOINTMENT

Fully funded PhD position (4-year trajectory subject to successful evaluation according to KU Leuven regulations)

Competitive salary according to KU Leuven doctoral scholarship scales

Expected start date: flexible, preferably October 2026

Location: Leuven, Belgium

Interested?

For more information please contact Prof. dr. Peter Witters, mail: [email protected] or Prof. dr. Bart Ghesquière, mail: [email protected].

APPLICATION PROCEDURE

To apply, please submit:

Motivation letter

Curriculum vitae

Academic transcripts

Contact details of two academic referees

You can apply for this job no later than August 10, 2026 via the online application tool

KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.

Heb je een vraag over de online sollicitatieprocedure? Raadpleeg onze veelgestelde vragen of stuur een e-mail naar [email protected]

av_timer Tewerkstellingspercentage: Voltijds

location_city Locatie: Leuven

timer Solliciteren tot en met:
10/08/2026 23:59 CET

bookmarks Tags: Chronische Ziekten en Metabolisme

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Je souhaite recevoir la dernière alerte Emploi pour les postes de ce type : engineering technician (leuven)

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Glycosphingolipid Dysregulation in Congenital Disorders of Glycysolation (CDG)

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